Profhilo, Rejuran & RD1 Skinboosters are three of the most frequently recommended injectable skin quality treatments — and three of the most frequently confused by patients trying to understand their options. They are all injectable treatments that improve skin quality from within. They are all delivered into the dermis. And they all produce improvements in hydration, firmness, and overall skin condition. But they work through completely different mechanisms, target different aspects of skin health, and are suited to different patient profiles and concerns.
This article explains what each one actually does, what it’s best suited for, and how to think about choosing between them — or combining them.
What Is a Skinbooster?
Skinbooster is a category term, not a single product. It refers to any injectable treatment designed to improve skin quality from within — as opposed to a traditional filler, which adds volume and structure. The skinbooster category includes Profhilo, Rejuran, RD 1, and several other products. Each has its own composition, mechanism, and clinical indication.
The common principle across skinboosters is that they are delivered intradermally — into the dermis itself — rather than into deep subcutaneous tissue as structural fillers are. Because they are placed within the skin rather than beneath it, they improve the quality of the skin tissue itself: its hydration, elasticity, collagen content, and overall health.
Profhilo Skinbooster: Bio-Remodelling Through High-Concentration HA
Profhilo skinbooster is often described as a “bio-remodelling” treatment. It contains the highest concentration of hyaluronic acid of any injectable currently available — 64mg/2ml — comprising a unique 1:1 ratio of high molecular weight and low molecular weight HA that is heat-stabilised rather than chemically cross-linked.
Because it is not cross-linked, Profhilo does not stay in one place after injection. Instead, it spreads through the dermis and hypodermis from its injection points, hydrating a large area of tissue while stimulating four types of collagen (types I, III, IV, and VI) and two types of elastin. This stimulation is what distinguishes Profhilo from a simple HA hydration treatment — it genuinely remodels the structural architecture of the skin rather than just filling it.
Profhilo is best suited for: patients with overall skin laxity, crepiness, and loss of firmness where the skin has lost structural integrity; patients in their thirties and above who want a comprehensive skin quality and firmness improvement; patients with dry, dehydrated skin that lacks bounce and elasticity. It is not primarily a brightening or pigmentation treatment — its main outcomes are firmness, hydration, and skin structure improvement.
Rejuran Skinbooster: Cellular Repair Through Polynucleotides
Rejuran Skinbooster (also known as PDRN or PN skinbooster) uses polynucleotides — fragments of salmon DNA — as its active ingredient rather than hyaluronic acid. Polynucleotides work by stimulating growth factor production in skin cells, promoting cellular repair and regeneration at a fundamental biological level. Unlike Profhilo skinbooster, which works primarily through hydration and collagen stimulation, Rejuran skinbooster works by improving the intrinsic cellular health and function of the skin.
The clinical outcomes of Rejuran skinbooster include improved skin elasticity and texture, strengthened skin barrier function, reduced skin sensitivity and reactivity, stimulation of new collagen and improved dermal thickness, and improvement of fine lines and acne scarring through cellular regeneration. As research published in the National Library of Medicine on polynucleotide injections for skin rejuvenation confirms, Rejuran skinbooster produces statistically significant improvements in skin elasticity, hydration, and texture through its cellular repair mechanism — with results that accumulate over a course of treatments.
Rejuran skinbooster is work best for patients with skin that has been damaged — by acne, sun damage, over-treatment, or barrier compromise; patients with post-acne scarring, enlarged pores, and textural irregularities; patients with sensitive, reactive skin that needs cellular-level repair rather than just hydration and also for younger patients (late twenties to thirties) whose primary concern is skin quality and resilience rather than firmness and laxity.
RD1 Skinbooster: Nourishment and Radiance
RD1 Skinbooster combines a low concentration of hyaluronic acid with a comprehensive complex of amino acids, antioxidants, minerals, and vitamins — nutrients that are naturally present in healthy skin but depleted by aging, UV exposure, and environmental stress. Its mechanism is nutritive: it replenishes the building blocks that the skin needs for cellular metabolism and repair.
RD1 skinbooster is best suited for patients seeking overall skin brightness, vitality, and radiance improvement, or patients with dull, tired-looking skin that lacks luminosity, or patients who want a gentle, comprehensive skin nourishment treatment rather than a structural intervention.
Skinbooster treatments are often paired together with Pico Laser as part of a brightening and toning programme.
Which Should You Choose?
The choice between these treatments depends on what your skin actually needs — which requires an honest assessment rather than guessing based on marketing language.
If your primary concern is skin laxity, crepiness, or loss of firmness — choose Profhilo skinbooster. If your primary concern is skin damage, textural irregularities, sensitivity, or post-acne concerns — choose Rejuran Skinbooster. If your primary concern is dullness, lack of radiance, and nutritive skin support — choose RD1 Skinbooster.
For many patients, the most effective approach combines these treatments in sequence or alternately — using Rejuran to repair damaged skin while using Profhilo to improve the structural foundation, then maintaining with RD1 Skinbooster for ongoing radiance. A tailored protocol designed around your specific skin profile will always outperform a single product used in isolation.
Consult our doctor at Kowayo Aesthetic Clinic for a skin assessment and a clear, honest recommendation on which skinbooster — or combination — is the right choice for your skin.
You can also explore our full skinboosters overview page to compare the options available at Kowayo.
“`