Ellanse PCL Collagen Stimulator with Kowayo Aesthetic Clinic

Recent medical research and Scientific Publications about PCL Ellanse Collagen Stimulator.

• Ellansé is a biodegradable dermal filler made of polycaprolactone (PCL) microspheres in a carboxymethylcellulose gel; it provides immediate volume and then stimulates neocollagenesis for longer‑lasting effect. Read more
• A recent narrative review (Aesthetic Plastic Surgery, 2024) describes Ellansé as a new‑generation collagen stimulator with “superior aesthetic results” and good safety, but also notes that more long‑term and site‑specific data are still needed. Read more
• Clinical recommendations paper (de Melo et al., 2017) summarises experience with PCL‑based fillers, reporting high patient and physician satisfaction for volume augmentation and rejuvenation in multiple facial areas. Read more
• An ongoing randomized split‑face clinical trial (NCT06984835) is directly comparing Ellansé‑S with Radiesse for nasolabial folds, with 126 subjects and 24‑month follow‑up to demonstrate non‑inferiority on WSRS improvement and duration of effect. Read more
• A large retrospective study of 780 patients, 1,111 treatments and 5,595 syringes of PCL filler (Ellansé) found mainly mild, self‑limited events: prolonged edema 4.5%, bruising 2.7%, malar edema 0.72%, transient lumps 0.45%, discoloration 0.18%; there were no intravascular events, nodules/granulomas or infections over 3 years. Read more
• Another safety review of ~490,000 syringes reported an overall adverse event rate of 0.049%, with swelling, small lumps/nodules, and inflammation/infection as the main events, again largely mild. Read more
• A 2025 case series describes the “iCare” technique using collagenase injections to dissolve Ellansé M nodules, with in vitro and in vivo data showing effective reduction of PCL nodules and resolution within minutes plus massage. Read more
• This is important because PCL fillers are not hyaluronidase‑responsive; the paper offers an emerging option for managing delayed‑onset nodules and addresses one of the main concerns around non‑HA stimulators. Read more
• Published clinical and case reports describe Ellansé for midface and cheek volumization, nasolabial folds, jawline, temples, forehead/temporal augmentation and lateral brow lift, emphasizing supraperiosteal and multilayer injections. Read more
• Stress proper patient selection, low injection volumes, and respect for vascular anatomy to minimize risks such as malar edema and vascular compromise. Read more